LifeBox utilizes intermittent flushing of the heart with a preservation fluid to extend its out-of-body viable time. It has been designed to be portable, with corresponding innovations to overcome challenges of power and weight. Hypothermic temperatures (4 to 8 degree Celsius) are maintained using a novel patent-pending cooling system which uses a refrigerant, fans, and sensors for temperature regulation. This reduces the weight of the system by an order of magnitude as compared to traditional thermoelectric cooling methods. Additionally, the heart chamber is equipped with multiple sensors that continuously capture data, which serves as an indicator of heart health. This data allows the surgeon at the recipient site to take critical decisions, potentially leading to improved chances of success. Conceptually, the system can also be extended for preservation of other organs which rely on active flushing as a means of preservation.